A Swiss Army Knife for Genomic Data
04-05-21
A good way to find out what a cell is doing—whether it is growing out of control as in cancers, or is under the control of an invading virus, or is simply going about the routine business of a healthy cell—is to look at its gene expression. Lior Pachter, Bren Professor of Computational Biology and Computing and Mathematical Sciences, has developed a complex software tool that enables the processing of large sets of genomic data in about 30 minutes, using the computing power of an average laptop. Like a Swiss Army knife, the tool can be used in myriad ways for different biological needs, and will help ensure the reproducibility of scientific studies. "The interdisciplinarity of our team was crucial to conceiving of and executing this project," says Pachter. "There are people in the lab who are computer scientists, biologists, engineers. Sina Booeshaghi is in the mechanical engineering department and brings the perspective of his design background and engineering." [Caltech story]
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MCE
CMS
Lior Pachter
Sina Booeshaghi
Untangling the Heat Paradox Along Major Faults
03-12-21
Nadia Lapusta, Lawrence A. Hanson, Jr., Professor of Mechanical Engineering and Geophysics, and graduate student Valère Lambert, seek to explain the size of the forces acting on "mature faults"—long-lived faults along major plate boundaries like the San Andreas Fault in California—in an effort to better understand the physics that drive the major earthquakes that occur along them. Understanding the physics that govern major earthquakes on different types of faults will help generate more accurate forecasts for earthquake threats. "We have a lot of data from large earthquakes along subduction zones, but the last really major earthquakes along the San Andreas were the magnitude-7.9 Fort Tejon quake in 1857 and the magnitude-7.9 San Francisco Earthquake in 1906, both of them before the age of modern seismic networks," Lapusta says. [Nature article] [Caltech story]
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MCE
Nadia Lapusta
Valère Lambert
Student-Led Moon Dust Shield Team Named Finalist in NASA Competition
02-16-21
As astronauts walk across the moon, land spacecraft on its surface, drive lunar rovers around, or complete other astronaut tasks, they kick up the dust, and that is a problem because it can cause premature wear on mechanical parts, damage to seals, and may pose a health risk for the people breathing it in. "The sun is shining directly on these particles and giving them an electric charge," says third-year Caltech undergraduate student Luis Pabon. "This causes it to stick to the astronaut's suit or to any sensors or cameras that you put out on the moon." The Caltech team's invention, named Habitat Orientable & Modular Electrodynamic Shield (HOMES), tackles the problem of moon dust entering a potential lunar habitat and wreaking havoc within. [Caltech story]
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GALCIT
MCE
Luis Pabon
Professor Yu-Chong Tai Elected to the National Academy of Engineering
02-09-21
Yu-Chong Tai, Anna L. Rosen Professor of Electrical Engineering and Medical Engineering; Andrew and Peggy Cherng Medical Engineering Leadership Chair; Executive Officer for Medical Engineering, has been elected to the National Academy of Engineering (NAE). Professor Tai was elected for "contributions to microelectromechanical system technologies and parylene-based biomedical microdevices." Election to the National Academy of Engineering is among the highest professional distinctions accorded to an engineer. Academy membership honors those who have made outstanding contributions to "engineering research, practice, or education, including, where appropriate, significant contributions to the engineering literature," and to "the pioneering of new and developing fields of technology, making major advancements in traditional fields of engineering, or developing/implementing innovative approaches to engineering education." [NAE release] [Caltech story]
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honors
MedE
Yu-Chong Tai
MCE
